Correlation of oxidative stress with 2-hour Plasma Glucose in normal subjects and diabetic families

L. A. CHUGHTAI, Z. A. LAGHARI, J. A. ZAI, Z.U.N. MUGHAL, J. WARSI

Abstract


Background: There is substantial proof that the hyperglycemia results in generation of reactive oxygen species (ROS), eventually lead to increased oxidative stress in various tissues that results in diabetic complications. This study evaluates the role of oxidative stress in three groups, viz. Diabetics (aged 22 to 60 years) and non-stressed controls and stressed controls (22 to 30 years). Method: The Study population from amongst the diabetic families were divided into three groups on the basis of clinical history, 2hPG and HbA1c. The blood samples of the normal control and stressed were taken for investigation of oxidative enzymes and were estimated spectro photo metrically. Results: The oxidative stress in diabetics and controls (stressed and non-stressed) were correlated with 2 h-PG (two hour plasma glucose) in serum samples collected from all the subjects. According to initial findings the correlation (at the 0.05 level, 2-tailed) was negatively correlated in the non-stressed controls. CAT, SOD, MD), VIT.C, VIT.E and positively in the GSH, NO. In stressed subjects (exercising) groups; it was negatively correlated in SOD, VIT.C, VIT. E and while it was positively correlated in CAT, GSH, MDA, NO. The correlation coefficient was significant in case of diabetics with CAT, SOD, NO, VIT.C and VIT.E. It is observed that there is relationship between oxidative stress and 2h-PG that shows close association with the changes in antioxidant defense system resulting in the complications of diabetes mellitus type-II. Conclusion: There is positive correlation of oxidative stress with 2h-PG normal persons, while it is negatively correlated with diabetic patients


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