Plasma levels of anti-inflammatory cytokine Interleukin-10 predict tuberculosis risk in type 2 Diabetes Mellitus

N. MALKANI, M. MUMTAZ, Z. ASLAM, A. YAQUB

Abstract


Diabetes mellitus is a highly prevalent disease leading to weakening of immune system and leading to other health problems. In the present study it was aimed to evaluate the prediction of increased risk of getting tuberculosis in diabetic patients based on plasma levels of cytokine IL-10.For this purpose three groups of subjects: 100 healthy controls, 100 patients with diabetes only, and 100 patients with tuberculosis and diabetes were examined. The demographic characteristics such as age, BMI and hematological parameters i.e., total white blood cell count, lymphocytes, neutrophils and platelets were measured. By using ELIZA in-vivo production of interleukin 10 (IL-10) was measured. One way ANOVA was applied to the data with LSD as post hoc test for the comparison between various groups. Patients with type 2 diabetes showed increased IL-10production and patients with both active tuberculosis and diabetes were found to have lower IL-10 levels 7.96 ± 0.31. The mean difference found was significant at p value of 0.05.


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