TESTICULAR TOXICITY OF LAMBDA CYHALOTHRIN INSECTICIDE IN MALE RABBITS (ORYCTOLAGUS CUNICULUS)

S. A. MEMON, S. A. SHAIKH, N. MEMON, M. A. SHAH, B. MAL, N. A. SHAH

Abstract


An attempt was made to investigate the toxic effects of Pyrethroid (Lambda Cyhalothrin) on testicular tissues in rabbits. In this context animals randomly divided in to one control group and two test groups. The test group animals were orally administrated 1/10th of LD50lamda cyhalothrin at 8 mg/kg. body weight/ day for 10 and 15 consecutive days. During experimental period clinical observations were recorded in the treated animals. Highly significant decline (P < 0.001) in the body weight and testicular weight was observed in both test groups as compared to control group. Histopathological observations revealed that the seminiferous tubules become elongated and picnosis was noted throughout the tubular space in the 10 days treated animals. Whereas 15 days exposed animals showed tumor/hypertrophy formation in the seminiferous tubules and interstitial spaces. Leydig’s cells eliminated and sheaths of the seminiferous tubules were broken down. Present study revealed that, lambda cyhalothrin insecticide showed drastic effects on the testicular tissues which can cause male reproductive disorders.

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