ENZYME ACTIVITY OF AKP, CPK, LDH AND S-GOT IN BLOOD SERUM OF MALARIAL PATIENTS

S. BALOCH, S.A. MEMON, G. S. GACHAL, M. BALOCH, M. SIKANDER

Abstract


Malaria  is  one  of  the  most  serious  tropical diseases in the world, such as in North America, South America, Asia and Africa. It has been a severe public health problem in Pakistan due to poor hygienic conditions; malnutrition borne non-defensive immunity system. Enzyme activity plays vital roles in metabolic pathways are expected to be severely disturbed in malarial patients. In present study blood serum Creatine phosphokinase (CPK), Alkaline phosphatase (AKP), Lactate dehydrogenase (LDH), and Glutamine oxalotransaminase (S-GOT) activity was evaluated in twelve malarial patients and in the same number of normal subjects using kit method on Microlab 300. The enzyme activity of AKP, LDH and S-GOT increases significantly, whereas, the activity of CPK decreases in malarial patients as compared to the control subjects. The blood serum enzyme activity determined for AKP was 160.42 U/L, for LDH 549.08 U/L, for S-GOT 43.830 U/L and for CPK it was 77 U/L and those for the normal subjects the activity was determined to be 123.75U/L, 291.17 U/L, 18U/L and 86.33U/L for AKP, LDH, S-GOT and CPK respectively.


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