ASSOCIATION OF BLOOD IL-6, CORTISOL AND HAEMODYNAMICS IN HEALTHY ADULTS WITH STRESS: A POSSIBLE ROLE IN EARLY ATHEROGENESIS

G. M. Qureshi, G. M. Seehar, A. M. Soomro, Z. A. Pirzado, S. A. Abbasi

Abstract


The stressful events might provoke immune alteration in human, which lead towards serious health disorders including ischemic heart diseases. Many studies demonstrated the association of IL-6 with cardiac problems particularly in middle age population. The stress linked changes in physiological parameters in young adults with no apparent heart disease is substantial. Therefore objective of study was to explore the association of altered IL-6, blood cortisol, and changes in haemodynamic variables during stressful life event. In this cross-sectional study, 114 subject participants were studied twice: during examination event as “stress study” and after two months period of conditioned rest they were examined again and taken as “control study”. Present results indicate that IL-6 values increased in stress significantly. Comparatively the haemodynamics and cortisol level in the subjects with ‘stress’ were found different from that of ‘non-stress’ controls, at significant level (p<0.001). Correlation of IL-6 with SBP and DBP was significant but interestingly non-significant with HR findings in stress, which need further studies. Conclusively this work paves a way for better understanding of the stress association with process of atherosclerosis in young age males, suggesting future studies on gender differences.


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